Free radical infact come from oxygen molecule that
chemically experience structure change sothat have level of high reactive and
naturally there is in body variously, but generally as a effect various process
of biochemical in the body, resulting from another side from process oxidize or
combustion of cell that goes on when breathing, cell metabolism, abundant doing
sport, inflammation, or environmental pollution like vehicle smoke, cigarette
smoke, and cosmic radiation.
Chemically, free radical be defined as a
atom/molecule/compound that have oneor more electron have not pairs, therefore
to get electron pairs so that free radical becomes very reactive to destroy
tissue and tended to react with molecule of body cell, and then generate
compound below par ( new free radicalwhich more reactive ) and begin reaction
which can destroy important cell.
Free radical that circulating in body will steal
electron that exist in another molecule like DNA and cell, so that will destroy
the DNA and cell. Generated damage can cause cell becoming unstabilize and have
potency will causing cancer, liver disease, arthritis, cataract, and another
degenerative disease, even also quicken process of aging.
Example of free radical is superoxida ( O2-),
hydroxyl ( OH-), nitroxida ( NO), peroxide hydrogen (H2O2), hypochlorite acid (
HOCL), thill ( RS-), etc. Degree of strength every free radical differ, and
riskiest compound is hydroxyl ( OH-) because have reactivity most high.
Free radical also there are in environment coming from air pollution, tobacco
smoke,evaporation of abundant alcohol, manure and preservative, ultra violet
ray,X-Rays, and ozone.
In fact, forming of free radical is biochemical
mechanism that normal. Free radical have the character as a medium that can
swiftly turned into substanceso that is not dangerous again for body. But, if
happened contact among freeradical with enzyme or unsaturated fatty acid
duplicate will generate damage of cell for example :
1. Damage of DNA.
Change of abnormal at certain gene
in body can generate is cancerous.
2. Damage of membrane cell.
If unsatiated fat acid
duplicate as a important component of cell membrane be attacked free radical
will cause structure and function of membrane change in astate of extreme and
finally kill cell at body tissue.
3. Damage of protein.
Happening damage of protein as
a effect of free radical attack including protein oxidation that resulting
damage of tissue as a protein place reside in. The example is damage of protein
at eyepiece resulting cataract.
4. Damage of lipid peroxide.
Damage of lipid peroxide
happened if unsaturated fat acid be attacked free radical so that will yield
peroxide then can cause damage of cell, and be assumed as a one of cause the
happening of various degenerative disease.
5. Process of aging.
Damage of tissue by free radical
will quicken process of aging, like lost of elasticity at tissues of collagen
and muscle, happen lipofuchsin at skin as aeffect of hoard from result of
combustion in cell.
6. Generate process of autoimmune.
Autoimmune is form
of antibody to an ordinary body cell and this matter can destroy body tissue and
very dangerous if continuously formed to overcome free radical.
Free radical able destroy body cell if excess free radical
at body or body lacking of antioxidant. This matter be caused free radical will
be neutralized antioxidant so that don't have ability again steal electron from
DNA and cellby giving electron to free radical.
.jpg)
0 komentar:
Posting Komentar