Rabu, 02 Mei 2012

LEUKOCYTES & ALLERGY


The term white blood cells or leukocytes is derived from Greek words "leukos" meaning white and "cytes" meaning cells.

The white blood cells are essential to the immune system and include :
  • Monocytes
  • Macrophages
  • Neutrophils
  • Basophils
  • Eosinophils
  • Lymphocytes
Lymphocytes are white blood cells that play a key role in both immunity and allergy. Lymphocytes are divided into two types and each type is responsible for a particular branch of the immune system, they are :

The T lymphocytes
The duty of the T-lymphocytes to be ready to directly shift into action to attack foreign substances ( cell-mediated immunity ).

The type of T-lymphocytes are :
  • Cytotoxic or killer T cells ( experts at "killing" )
  • TH cells ( others assist the immune esponse and are termed "helper" cells )
Depending on the proteins they release, the TH cells are further divided into :
  • TH1 ( infection fighters )
  • TH2 ( allergy promoters )
The B lymphocytes
The partners of the T-lymphocytes are the B-lymphocytes. B-lymphocytes are tiny antibody factories that produce antibodies to help destroy foreign substances when stimulated to do so by the TH cells.

Basophils and eosinophils are other white blood cells that play an important role in allergy. T cells often call these cells into action in allergic conditions. Blood levels of eosinophils are commonly elevated in people with asthma and other allergic diseases.
Cytokines are a diverse group of proteins that are released by lymphocytes and macrophages in response to an injury or activation, such as by an allergen.
They act as chemical signals that "step up" or "step down" the immune reaction.

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