Triglyceride is a fatty substance that is
composed of three fatty acids. Like cholesterol, triglyceride in the blood
either comes from the diet or the liver.
- Obesity
- Low levels of HDL- cholesterol
- Insulin resistance
- Poorly controlled diabetes mellitus
- Small dense LDL cholesterol particles
Hypertriglyceridemia can often be caused by :
Genetic factors
In some people, abnormally high triglyceride levels ( hypertriglyceridemia ) are inherited. Examples of inherited hypertriglyceridemia disorders include :
Genetic factors
In some people, abnormally high triglyceride levels ( hypertriglyceridemia ) are inherited. Examples of inherited hypertriglyceridemia disorders include :
- Mixed hypertriglyceridemia
- Familial hypertriglyceridemia
- Familial dysbetalipoproteinemia
Non-genetic factors
- Obesity
- Excessive alcohol intake
- Diabetes mellitus
- Kidney disease
- Estrogen- containing medications such as birth control pills
The step in in treating hypertriglyceridemia is :
The first step
The first step
- Low fat diet with a limited amount of sweets
- Regular aerobic exercise
- Loss of excess weight
- Reduction of alcohol consumption
- Stopping cigarette smoking
- In patients with diabetes mellitus, meticulous control of elevated blood glucose is also important.
The second step
Medications are necessary in decreasing triglyceride.
Fibrates ( such as Lopid )
Lopid not only decreases triglyceride levels but also increases HDL cholesterol levels and LDL cholesterol particle size.
A relatively new medicine, fenofibrate ( Tricor ), shows promise as an effective agent in lowering serum triglyceride levels as well as raising HDL levels, particularly in patients who have had suboptimal responses to Lopid.
In some patients, a combination of Lopid or Tricor with adjunctive statin therapy may be prescribed. While this combination is often effective in patients with complex lipid disorders, the potential for side effects may be increased and such patients should be under strict medical supervision.
Nicotinic acid
Nicotinic acid lowers triglyceride levels, increases HDL cholesterol levels and the size of LDL cholesterol particles.
The statin drugs
Statin medications have been found effective in decreasing triglyceride as well as LDL cholesterol levels and, to a lesser extent, in elevating HDL cholesterol levels.
Medications are necessary in decreasing triglyceride.
Fibrates ( such as Lopid )
Lopid not only decreases triglyceride levels but also increases HDL cholesterol levels and LDL cholesterol particle size.
A relatively new medicine, fenofibrate ( Tricor ), shows promise as an effective agent in lowering serum triglyceride levels as well as raising HDL levels, particularly in patients who have had suboptimal responses to Lopid.
In some patients, a combination of Lopid or Tricor with adjunctive statin therapy may be prescribed. While this combination is often effective in patients with complex lipid disorders, the potential for side effects may be increased and such patients should be under strict medical supervision.
Nicotinic acid
Nicotinic acid lowers triglyceride levels, increases HDL cholesterol levels and the size of LDL cholesterol particles.
The statin drugs
Statin medications have been found effective in decreasing triglyceride as well as LDL cholesterol levels and, to a lesser extent, in elevating HDL cholesterol levels.
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